Contraindications include diabetes, pregnant and lactating women, people with glaucoma, people who are taking blood-thinning medications, Cortisone, Steroids, Acutaine, Retin-A, Renova, You must have written permission from your physician if you are taking Coumadin or Heparin. People with skin diseases such as psoriasis, eczema, undiagnosed rashes and blisters, those with allergies to makeup or colors, and those with easily triggered post inflammatory hyperpigmentation are not good candidates. Herpes simplex can be a contraindication. Acyclovir needs to be taken 1 week prior and 1 week after any lip treatment.